Real time patient side monitoring of amino acids in Inherited Metabolic Disorders.
Allworth Diagnostics is an early-stage health technology company developing real time home monitoring solutions for Inherited Metabolic Disorders (IMDs). Our products will enable patients and caregivers to regularly measure blood amino acid levels from the convenience of their home and integrate test results into personalised data management portals for trend analysis and dissemination to their healthcare providers.
Inherited Metabolic Disorders are a group of medical conditions where an underlying genetic change impacts the body’s ability to breakdown everyday food constituents.
Our proprietary recombinant enzyme technology coupled with advanced optical sensors and cloud-based data algorithms enables the precise measurement of blood based amino acids, the building blocks of our dietary proteins. We are experts in developing enzymatic tests for difficult to measure targets.
Utilising our proprietary enzyme technology and advanced optical sensors, Allworth Diagnostics has developed a blood monitoring and data management system for IMDs from a single drop of blood in 2 minutes, focusing initially on Phenylketonuria (PKU), Galactosemia (GAL) and Maple Syrup Urine Disease (MSUD).
Inherited metabolic disorders refer to a group of medical conditions, caused by genetic defects that interfere with the body’s metabolism.
Our metabolism is a complex set of thousands of biochemical reactions used by the human body for a range of life sustaining purposes, including energy production from the food we eat. Each reaction involves multiple molecules including hormones and enzymes. Some people are born with a genetic change that inactivates one or more of these key molecules. These individuals cannot breakdown specific amino acid or carbohydrate constituents of everyday foods. The accumulation of these molecules in the blood stream leads to a range of physical and neurocognitive symptoms. Collectively, these conditions are known as Inherited Metabolic Disorders and include
- Phenylketonuria (PKU)
- Maple Syrup Urine Disease (MSUD)
Diagnosis of the most prevalent Inherited Metabolic Disorders usually occurs in the first few days of life through national screening programs based on the well know heel prick test. Once diagnosed, clinical management for Inherited Metabolic Disorders is life long and is typically based on dietary management, supplementation and often pharmaceutical therapy. Allworth Diagnostics products are monitoring tools, providing the Inherited Metabolic Disorder community with a real time solution to regularly monitor these critical metabolite levels in their blood from the convenience of their home.
Phenylketonuria (PKU) is an Inherited Metabolic Disorder affecting over 450,000 people worldwide. Individuals with PKU lack the enzyme to break down the common amino acid Phenylalanine, prevalent in many everyday foods. This leads to an accumulation of phenylalanine in the blood and a number of physical and neurocognitive symptoms.
Irrespective of treatment method, either through dietary management or pharmaceutical therapy, the goal for clinical management of PKU is maintaining blood phenylalanine levels within a target range.
The current methodology for blood phenylalanine monitoring is based on patients self-collecting dried blood spot samples and mailing them to a centralised laboratory for analysis on a large central lab system. Although this is a long-established method, the process has numerous sources of variation and error and only returns results to patients 4-10 days after they have collected the sample.
Allworth Diagnostic’s Phenylalanine Monitor provides an actionable result from a fingerstick drop of blood in 2 minutes.
The convenience and ease of use of our system provides a key tool for regular, recurrent monitoring with instant result feedback. Use with our smartphone app and cloud-based data management system, allows patients, caregivers and healthcare professionals access to insightful trend analysis to improve clinical management and the quality of care for the PKU community.
Enzymatic test technology is one of the most established technologies in the diagnostic industry, used in many well know tests including diabetic blood glucose and continuous glucose monitoring.
Our proprietary enzymes have been engineered to deliver enhanced analytical performance in unique biochemical reaction conditions.
We have developed a novel enzyme detection system to measure amino acids directly from whole blood and integrated our enzyme technology into single use tests strips, which are read on our advanced optical reader.
Following each test, the result is transmitted to a secure cloud-based algorithm for data analytics and integration with patient management and healthcare tools.
Allworth Diagnostics are developing a pipeline of near-patient disease management tools for Inherited Metabolic Disorders including
- Phenylketonuria (PKU)
- Maple Syrup Urine Disease (MSUD)
We are also applying our proprietary enzyme technology towards near patient applications in enzyme deficiency disorders including
- Biotinidase Deficiency
- Glucose-6-Phosphate Dehydrogenase Deficiency (G6PDH)
Our monitoring systems are key tools for the management of Inherited Metabolic Disorders and add value for patients, caregivers, healthcare professionals, food supplement and drug therapy solutions across the Inherited Metabolic Disorder community. If you are active in the Inherited Metabolic Disorder community and interested in partnering with Allworth Diagnostics, please get in touch.
Our mission is to improve the management of Inherited Metabolic Disorders, through the provision of convenient, accurate and instant monitoring tools from a fingerprick of blood.
If you have a can-do attitude, relevant qualification or experience and are interested in bringing novel med-tech from the R&D lab to the market or a career making a difference to the lives of people with Inherited Metabolic Disorders, please get in touch.
If you would like more information, please contact us today
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